Several obstacles must be overcome to increase the international acceptance of Japanese functional food products, such as the need for basic science, surmounting the difficulties of human intervention trials using healthy subjects, and the need for highly effective preclinical markers that can contribute to observing even a miniscule breakdown of a healthy state ( Figure 5).
#ENDOWED CHAIR VERIFICATION#
To achieve this, it will be necessary to develop novel methods, including verification of each functionality by human intervention. In particular, research into functional foods for the next generation needs to explore cognitive activation and locomotion improvement and to provide evidence that these functionalities are effective for enhancing quality of life. 44–75 Since 2015, when a national system for approval of functional food claims was established, related studies have gradually adopted a new approach in terms of research objects and methodologies. The scientific papers originating from the endowed chair are widely cited in top-tier journals and were written in collaboration with ILSI Japan-member food companies. National project “SIP” as the next-generation agriculture subprogram. 3 In collaboration with some food companies, 4–14 many papers were published in high-level journals. In the first 5 years of the endowed chair, statistical nutrigenomics was launched, revealing a significant expression of a number of transcriptomes in target tissues and organs following food consumption ( Figure 1). 1, 2 CHAIR ACTIVITIES AND RESULTS Term I activities (December 2003 to November 2008) This goal was posited on the fact that the genomes of major animals, including humans, plants, and microbes had already been verified.
The main purpose of this endowed chair was to assist in a global understanding of the importance of genomics-based functional food science and technology – in collaboration with ILSI Japan-member companies – for the purpose of introducing a new wave of technology into the national and international food industry. The activities continued for the subsequent 15 years, encompassing 3 terms, until March 31, 2019. This endowed chair was founded at the Graduate School of Agricultural and Life Sciences, The University of Tokyo, on December 1, 2003.
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